Select Epstein-Barr Virus–Associated Digestive Tract
Lesions for the Practicing Pathologist

Zainab I. Alruwaii, MD; Elizabeth A. Montgomery, MD

Context.—Epstein-Barr virus is a ubiquitous oncogenic virus. During the past 5 decades, the virus has been linked to several disease entities, both neoplastic and nonneoplastic.
Several Epstein-Barr virus–associated conditions affect the digestive organs, ranging from mild transient inflammatory conditions to more debilitating and even
fatal diseases.

Objective.—To discuss the clinicopathologic aspects of some newly or recently recognized Epstein-Barr virus– related conditions encountered in the digestive system and their therapeutic implications.

Data Sources.—Published peer-reviewed literature was reviewed.

Conclusions.—This article highlights the importance of recognizing the discussed lesions because they influence the direct clinical management or serve as a potential predictive marker for therapy.

(Arch Pathol Lab Med. 2021;145:562–570; doi: 10.5858/ arpa.2019-0703-RA)